Gabapentin 600 mg is commonly prescribed for nerve pain, seizures, and anxiety, but many users wonder if it can affect mood. While not everyone experiences it, mood changes like irritability, depression, or unusual emotional shifts have been reported by some patients taking Gabapentin 600 mg. These effects are more likely if you're new to the medication or if your dose has recently increased. It’s important to track any emotional changes and discuss them with your doctor, as mood-related side effects might require dose adjustment or a switch in treatment.